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KMID : 1100220050040010006
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Dementia and Neurocognitive Disorders
2005 Volume.4 No. 1 p.6 ~ p.9
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Progressive Non-fluent Aphasia
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Jeong Jee-Hyang
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Abstract
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Progressive non-fluent aphasia (PNFA) is a syndrome comprising loss of ability to communicate fluently with relative preservation of single word comprehension and other non-linguistic abilities. It is now regarded as a subtype of Mesulam’s Primary progressive aphasia with many different neuropathologic findings including Dementia Lacking Distinctive Histology (DLDH), Pick’s disease, Corticobasal degeneration, Creutzfeldt-Jakob Disease and rarely Alzheimer’s disease. The clinical manifestation is characterized by prominent dysfluency with bucofacial or speech apraxia often leading to mutism. Others like asymmetric motor sign or frontal releasing signs can be observed. Brain imaging reveals profound left hemispheric dysfunction with distinct involvement of the left insular and frontal opercular areas. Treatment is mainly symptomatic. Speech therapy can be effective if appropriate. When behavior problem is present, medical treatment is optional unless severe.
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KEYWORD
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Progressive non-fluent aphasia, Language, Neuropathology
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